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Indications and Usage

Diflucan is effective drug against most of the known species of fungi, dermatophytes (infect hair, nails, the stratum corneum and epidermis) and dimorphic fungi that can develop as a moldy or yeast form. The active substance of Diflucan is Fluconazole that suppresses fungal cells sterol synthesis necessary for the formation of cell membranes. The maximum concentration of the substance in the blood is within 30-90 minutes after intake due to the rapid absorption of Diflucan. The half-life of Fluconazole is equal to 26-30 hours, so a patient can take the drug only once a day.

Diflucan is used for treatment in the following cases:

  • genital candidiasis
  • deep endemic mycoses
  • cryptococcosis  (as well as cryptococcal meningitis and infections)
  • acute and recurrent vaginal candidiasis
  • relapse prevention cryptococcosis in immunocompromised patients
  • generalized candidiasis (known as thrush damage of the internal organs)
  • candidiasis of the mucous membranes
  • mycosis of the skin of various localization (disease caused by parasitic fungi)
  • prevention of fungal infections in people with malignant tumors when radiation therapy and cytotoxic chemotherapy can trigger the development of such infections

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Instruction for Medical Use

It is hard to meet a woman who has never faced yeast infection. This disease causes not only itching, irritation, discomfort, but also deterioration of health. To date, the thrush is not a sentence. The main thing is to start the treatment as soon as possible. There is a great many of medications for the treatment of thrush in modern pharmacology. Diflucan is one of them.

You will be able to resort to using this drug almost for any fungal diseases treatment. It should be noted that you can start the course of therapy even before you get the results of sowing and other necessary tests. So, Diflucan can combat cryptococcosis, generalized candidiasis, mucosal candidiasis, genital candidiasis, mycosis of the skin, as well as deep endemic mycoses.

Diflucan is produced in the form of capsules containing 50 mg, 100 mg or 150 mg of Fluconazole, powder for oral suspension and intravenous solution. Diflucan capsules are used in different doses, the magnitude of which depends on the nature and severity of the disease. Cryptococcal infection, cryptococcal meningitis and invasive (spread throughout the body) candida infection is cured by taking of 400 mg of Fluconazole on the first day and 200-400 mg on subsequent days.

The duration of treatment depends on the clinical efficacy of the drug. Patients with yeast on the oral mucosa, gums, cheeks, tongue, and pharynx take Diflucan for 1-2 weeks of 50-100 mg a day. The same scheme is used for treatment of other Candida infections of the mucous membranes (except genital candidiasis); only the duration of the use of Diflucan in such cases lasts for 2-4 weeks.

Diflucan has a good permeability characteristic in tissue and body fluids, so the concentration of drug in the bronchial secretions, saliva, and cerebrospinal fluid concentration corresponds to the blood. A higher number of Fluconazole accumulated in the stratum corneum. Diflucan is excreted by the kidneys.

Side effects of Diflucan are commonly met in patients who take the drug without doctor's consultation.

The most widespread are the following:

  • headache, dizziness, convulsions, nausea
  • flatulence, abdominal pain, vomiting
  • dyspepsia, toxic effects on the liver, abnormal liver function
  • jaundice, hepatitis, hepatocyte necrosis
  • agranulocytosis, neutropenia, thrombocytopenia
  • increased cholesterol levels, hypokalemia, etc.

Diflucan can be used when a patient has AIDS or cancer to prevent during radiotherapy and chemotherapy.  This drug is prescribed in cases of fungus treatment in children. Furthermore, in such cases, kids are under the constant supervision of doctors. The dose of drug is prescribed depending on the age of the patient, as well as the nature and severity of the fungal infection. If you suffer from such unpleasant things as thrush, a single dose of Diflucan helps almost always in this case. If a fungal infection is severe, so therapy should be carried out as long until all signs of the disease disappear.